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NIH Research Matters

August 25, 2014

A female Anopheles gambiae mosquito feeding on a human.

Drug Prevents Malaria in High-Risk Region

A combination drug treatment substantially reduced malaria in young children in Africa. The treatment could help reduce the disease burden among those most at risk.

Person getting an injection.

Chikungunya Vaccine Shows Promise

A chikungunya vaccine gave encouraging results in an early-stage clinical trial. A vaccine could prevent outbreaks of the disease, which recently reached the U.S. mainland.

Glutamate receptor

Structural States of a Brain Receptor Revealed

Scientists determined the detailed structural states of the glutamate receptor, which is involved in learning, memory, and several diseases.

August 18, 2014

Blurred image of person walking toward camera.

Over 100 Genetic Sites Tied to Schizophrenia

Researchers found 108 genetic regions linked to schizophrenia, including 83 previously unrecognized. The findings suggest new avenues for potential treatments.

Inflamed blood vessels

Gene Linked to Rare Inflammatory Disease in Children

Scientists identified a gene that underlies a rare but devastating autoinflammatory condition in children. The study suggests a potential treatment for this and related diseases.

Brain tissue of a CJD patient

Detecting Human Prion Disease

New tests rapidly and accurately diagnose Creutzfeldt-Jakob disease, an incurable and ultimately fatal neurodegenerative disorder. Such tests would have important clinical and research uses.

July 28, 2014

Therapist working with a patient who has low vision.

Preventing Depression From Age-Related Vision Loss

Depression is a common risk for people who’ve lost vision from age-related macular degeneration. A type of therapy called behavior activation can cut this depression risk in half.

Brown fat in neck and upper back region.

Cool Temperature Alters Human Fat and Metabolism

Men exposed to cool temperatures for a month had an increase in brown fat along with changes in metabolism. The finding hints at new approaches to conditions such as obesity and diabetes.

Tumor cells.

Isolated Cancer Cells May Lead to Personalized Treatments

Scientists used a novel microchip-based method to isolate and grow tumor cells circulating in blood. The technique provides an important step toward personalizing cancer therapy.

July 21, 2014

Mother holding a baby.

Drug Improves Birth Rates for Women with Ovary Disorder

The drug letrozole is more effective than standard therapy in increasing live births for women with polycystic ovary syndrome—a leading cause of female infertility.

DNA molecule unwinding from a chromosome inside the nucleus of a cell.

Gene Changes Identified in Most Common Lung Cancer

Researchers identified DNA alterations that are involved in the development of lung adenocarcinoma. The findings may lead to more targeted therapies to treat this deadly cancer.

Supercooled rat liver.

Preserving Livers for Transplantation

A new technique increased the time that rat livers can remain viable outside the body. If the approach succeeds in humans, it could aid organ transplant efforts.

July 14, 2014

Blood cells.

Stem Cell Transplant Reverses Sickle Cell Disease in Adults

Adults with severe sickle cell disease were successfully treated with a stem cell transplant approach that doesn't require extensive immune-suppressing drugs.

Students in Chinese classroom.

Low Levels of Lead Linked to Problems in Children

Low blood levels of lead were associated with increased behavioral and emotional problems in young children.

Cilia in liver cells.

Protein Critical to Cilia Development

Researchers gained insights into a key protein involved in ciliopathies, a class of genetic disorders that arise from defects in hair-like extensions called cilia that are found on cells throughout the body.

June 30, 2014

DNA sequence and helix models, with a man in the background

Rare Mutations Reduce Heart Disease Risk

Variations in a gene called APOC3 are associated with lower triglyceride levels and reduced risk of heart disease. The finding suggests new approaches to lower heart disease risk.

Man remembering something.

Storing Memories of Recent Events

Research into the mechanisms that underlie our ability to remember events could yield insights into the memory problems that come with normal aging and dementia.

Molecular Insights into a Target for Multidrug Resistance

The structure of a protein that bacteria need to spread the genes for antibiotic resistance could spur the development of novel drugs to combat multidrug-resistant bacteria.

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About NIH Research Matters

Editor: Harrison Wein, Ph.D.
Assistant Editors: Vicki Contie, Carol Torgan, Ph.D.

NIH Research Matters is a weekly update of NIH research highlights from the Office of Communications and Public Liaison, Office of the Director, National Institutes of Health.

Research News from NIH and Grantees

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This page last reviewed on August 25, 2014

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