NIH Research Matters
July 21, 2014
The drug letrozole is more effective than standard therapy in increasing live births for women with polycystic ovary syndrome—a leading cause of female infertility.
Researchers identified DNA alterations that are involved in the development of lung adenocarcinoma. The findings may lead to more targeted therapies to treat this deadly cancer.
A new technique increased the time that rat livers can remain viable outside the body. If the approach succeeds in humans, it could aid organ transplant efforts.
July 14, 2014
Adults with severe sickle cell disease were successfully treated with a stem cell transplant approach that doesn't require extensive immune-suppressing drugs.
Low blood levels of lead were associated with increased behavioral and emotional problems in young children.
Researchers gained insights into a key protein involved in ciliopathies, a class of genetic disorders that arise from defects in hair-like extensions called cilia that are found on cells throughout the body.
June 30, 2014
Variations in a gene called APOC3 are associated with lower triglyceride levels and reduced risk of heart disease. The finding suggests new approaches to lower heart disease risk.
Research into the mechanisms that underlie our ability to remember events could yield insights into the memory problems that come with normal aging and dementia.
The structure of a protein that bacteria need to spread the genes for antibiotic resistance could spur the development of novel drugs to combat multidrug-resistant bacteria.
June 23, 2014
Hormone replacement therapy restored bone mineral density in women with primary ovarian insufficiency. The findings provide important treatment guidance.
Exposure to certain allergens and bacteria within the first year of life may protect children from wheezing and allergies. The study’s findings suggest asthma prevention strategies.
Researchers induced human stem cells to create a 3-D retina structure that responds to light. The finding may aid the study of eye diseases and could eventually lead to new therapies.
June 9, 2014
Researchers completed a draft map of the human proteome—the set of all proteins in the human body. The map will help advance studies of human health and disease.
A small dose of laser light activated stem cells in rat molars to generate dentin, a major component of teeth. The finding may lead to new approaches to tooth repair.
Scientists determined the structure of the NMDA receptor, an ion channel involved in many brain-related illnesses. The finding may aid in the development of future therapies.
June 2, 2014
Structured physical activity helped vulnerable older people maintain their mobility. The new study shows that moderate exercise might benefit even frail seniors.
Researchers gained insights into how cells in the auditory system become organized to hear different frequencies. The findings could lead to new approaches for treating hearing loss.
A 3-D liver-inspired device made of hydrogel and nanoparticles can remove toxins from blood. The device provides a proof-of-concept model for new detoxification techniques.
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About NIH Research Matters
Editor: Harrison Wein, Ph.D.
Assistant Editors: Vicki Contie, Carol Torgan, Ph.D.
NIH Research Matters is a weekly update of NIH research highlights from the Office of Communications and Public Liaison, Office of the Director, National Institutes of Health.