August 2010 NIH Audio Reports Archive
August 31, 2011
August 17, 2011
In Mouse Study, Researchers Discover New Mechanism for Clearing Blockages from Smallest Blood Vessels
Researchers have identified in mice a previously unknown protective mechanism by which the smallest blood vessels remove blood clots and other blockages from the brain. The findings provide insights into mechanisms that may be involved in age-related cognitive decline, Alzheimer's disease and recovery from stroke.
August 2, 2011
Scientists have discovered that a gene linked to Alzheimer's disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the National Institutes of Health, shows the presenilin 1 (PS1) gene is essential to the function of lysosomes, the cell component that digests and recycles unwanted proteins. However, mutations in the PS1 gene—a known risk factor for a rare, early onset form of Alzheimer's disease—disrupt this crucial process.
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