|FOR IMMEDIATE RELEASE
Tuesday, November 21, 2000
NIAAA Press (301) 443-3860
Research Insights into Alcoholism and Alcohol Abuse Highlighted in 10th Special Report
- Genetics of alcoholism. Two studies have found evidence of genes
on specific chromosomes influencing susceptibility to alcoholism. The ongoing
Collaborative Study on the Genetics of Alcoholism (COGA), which involves
987 individuals from high-risk families, reported suggestive evidence of
genes on chromosomes 1 and 7 involved in alcoholism. An early report from
the study also reported weaker evidence of such a gene on chromosome 2.
Another study from NIAAA’s Laboratory of Neurogenetics, based on 152 members
of a southwestern Native American tribe, reported suggestive evidence for
a gene influencing susceptibility to alcoholism on chromosome 11. Both studies
reported finding evidence of a gene that was protective against alcoholism
in a region of chromosome 4.
- Heavy drinking during pregnancy and fetal brain development. Applying
advances in neuroimaging and cellular and molecular biology, alcohol researchers
are gaining an increasingly clear picture of the physical nature of alcohol-induced
damage to the developing brain and the mechanisms that cause the damage.
Imaging studies have demonstrated structural abnormalities in certain brain
regions, whereas other regions seem to be spared. Research also shows that
a number of deficits in cognitive and motor functions are linked to prenatal
alcohol exposure, while other functions appear to remain intact. These studies,
as well as basic research on the mechanisms of prenatal alcohol damage,
support the notion that alcohol has specific, rather than global, effects
on the developing brain.
- Preventing underage drinking. One major study, the Community Trials
Project, found that sales clerks in alcoholic beverage outlets were half
as likely to sell alcohol to minors in communities with programs that trained
clerks, enforced underage sales laws, and raised awareness of increased
enforcement through the media. Another large study, Project Northland, showed
that a multi-year program involving schools, parents, peers, policy-makers,
and businesses can effectively reduce underage drinking if the intervention
begins before adolescents begin to use alcohol. The 10th Report
also describes the search for the roots of alcohol problems in adolescence
and later life stages, through multidisciplinary research on social, cultural,
psychological, and biological influences.
- Reducing alcohol-related traffic crashes. The 10th Report
presents many studies on the effectiveness of laws, public policies, community
programs, and individual actions to deter drunk driving. A number of studies
have focused on State laws that make it a criminal offense to drive with
a blood alcohol concentration (BAC) over a certain limit, which in most
States is 0.10 percent. New research shows that States that reduce the legal
BAC limit to 0.08 percent experience a significant drop in fatal crashes
related to alcohol, and that this decrease is distinct from the effects
of other drunk driving measures.
- Chronic alcohol use and the brain. Studies in animal models are
revealing how changes in the brain from chronic alcohol consumption underlie
such features of alcoholism as tolerance (lowered sensitivity to the intoxicating
effects of alcohol), withdrawal, and craving. This work is helping scientists
understand the biological basis for the motivation to drink too much and
the mechanisms through which alcohol causes lasting damage to the brain
in some individuals who consume alcohol heavily.
- Damage to body organs. Research on how alcohol damages body organs
is providing information that may be used in developing novel treatments.
For example, a variety of evidence suggests that liver damage results from
changes in immune function, suggesting the potential of immune-based treatments.
- Helping patients to reduce alcohol use and related problems. When
patients are found to be at-risk or problem drinkers, but not alcohol dependent,
health care providers can significantly reduce alcohol use and related problems
by providing a quick form of counseling called "brief intervention." Research
shows that brief interventions delivered in primary care settings can decrease
alcohol use for at least a year in persons who drink above recommended limits.
- Medications for treating alcoholism. Advances in neuroscience have
paved the way for medications that operate at the molecular level of brain
processes that influence alcohol addiction. Studies show that the medication
naltrexone and a similar compound, nalmefene, help reduce the chance of
heavy drinking when abstinent individuals relapse; that a medication called
acamprosate may prevent relapse; and that when patients with co-existing
depression take antidepressants, their alcoholism treatment outcomes improve.
The report contains eight chapters: (1) Drinking Over the Life Span: Issues
of Biology, Behavior and Risk, (2) Alcohol and the Brain: Neuroscience and
Neurobehavior, (3) Genetic and Psychosocial Influences, (4) Medical Consequences,
(5) Prenatal Exposure to Alcohol, (6) Economic and Health Services Perspectives,
(7) Prevention, and (8) Treatment. Each chapter is divided into two to six
subsections that can be downloaded individually in PDF format from the NIAAA
Bound copies of the entire 492-page report can also be ordered by writing
to: National Institute on Alcohol Abuse and Alcoholism, Publications Distribution
Center, P.O. Box 10686, Rockville, MD 20849-0686.
The NIAAA produced the 10th Special Report to the U.S. Congress on Alcohol
and Health with guidance from a distinguished editorial advisory board
and contributions from some of the world’s leading alcohol researchers. A
component of the National Institutes of Health, NIAAA funds more than 90 percent
of the alcohol abuse and alcohol addiction (alcoholism) research in the United