|EMBARGOED FOR RELEASE
Friday, January 28, 2000
Newly Updated HIV Treatment Guidelines for Adults and Adolescents Available on the World Wide Web
- restoration and/or preservation of the patient's
- improvement of their quality of life
- reduction of HIV-related illness and death.
The new Guidelines also delineate tools that may help achieve these goals,
- maximizing patient adherence to a regimen
- selecting "user-friendly" regimens when possible
- prescribing drugs in a rational sequence in order to
preserve future treatment options
- utilizing drug resistance assays when treatment fails.
The Panel also has reorganized its recommendations for the use of
antiretroviral drugs in the initial therapy of HIV infection. Previously,
drugs were placed in the "Preferred" category on the basis of their ability
to suppress plasma viral load. In keeping with the newly elaborated goals
of therapy, considerations such as pill burden, dosing frequency, food
requirements, convenience, toxicity and drug interaction profiles underpin
the new recommendations.
The updated Guidelines' "Strongly Recommended" category now includes a
small number of drugs the Panel feels can accomplish many therapeutic goals
with minimal negative effects on an HIV-infected individual's quality of
life. Other potent drugs that can also suppress plasma viral load but do so
at a high cost to quality of life are now included under the heading
"Recommended as Alternatives."
Finally, a new hypertext link to detailed information on the use of
antiretroviral drugs in pregnant women has been added. This information
will help physicians select the most appropriate antiretroviral regimen for
their HIV-infected patients who are pregnant.
Co-conveners of the Panel on Clinical Practices for the Treatment of HIV
Infection are Eric Goosby, M.D., on behalf of the Department of Health and
Human Services, and Jennifer Kates, M.A, M.P.A., on behalf of the Henry J.
Kaiser Family Foundation. Oren J. Cohen, M.D., NIAID Assistant Director
for Medical Affairs, serves as the Panel's Executive Secretary.
NIAID is a component of the National Institutes of Health (NIH). NIAID
conducts and supports research to prevent, diagnose and treat illnesses such
as HIV disease and other sexually transmitted diseases, tuberculosis,
malaria, asthma and allergies. NIH is an agency of the U.S. Department of
Health and Human Services.
The Henry J. Kaiser Family Foundation, based in Menlo Park, CA, is an
independent philanthropy focusing on the major health care issues facing the
nation. The Foundation is not associated with Kaiser Permanente or Kaiser
Press releases, fact sheets and other NIAID-related materials are available
on the NIAID Web site at www.niaid.nih.gov. HIV-related information is also
available on the Kaiser Family Foundation Web site at