|FOR IMMEDIATE RELEASE
Wednesday, April 15, 1998
Bill Grigg, NIEHS|
or (919) 541-2605
Tom Hawkins, NIEHS
Last Comment Sought on Agents Proposed for Report on Carcinogens;
A Final for Data on Saccharin, and a Re-review of Dioxin Announced
Final comment was also requested for additional substances to be listed as "reasonably anticipated to be a human carcinogen":
- The adequacy of existing epidemiology data, particularly as it relates to reported increased incidences of bladder tumor formation in certain subpopulations.
- The mechanism of urinary bladder tumor formation in male rats as it relates to other test species and to humans.
- Chloroprene, a component of adhesives in food packaging; phenolphthalein, a cathartic recently removed from popular nonprescription laxatives following NIEHS studies; tetrafluoroethylene, used in the production of Teflon, and trichloroethylene, a solvent.
NTP said that the NTP Board subcommittee's re-review of dioxin need not delay its listing in the ninth Report on Carcinogens, which is planned for next year. Kenneth Olden, Ph.D., director of the NTP and the NIEHS, said he has no argument with the recommendation to upgrade dioxin from "reasonably anticipated" to "known human carcinogen" but wanted to make sure the review crossed every "t" and dotted every "i" in this first set of actions following recent changes in the criteria and procedures for listing agents in the Report.
A press release on the advisory council's review of these substances may be obtained at http://www.niehs.nih under news and publications or by telephoning the contact listed at the beginning of this release. The FR notices are on page 13418 (March 19) and page 18435 (April 15).
Comment should be sent to Dr. C. W. Jameson, NTP Report on Carcinogens, EC-14,
P.O. Box 12233, Research Triangle Park, NC 27709, by May 19, 1998, or, in the case of dioxin (TCDD) June 15.