NIH Research Matters
August 25, 2014
A combination drug treatment substantially reduced malaria in young children in Africa. The treatment could help reduce the disease burden among those most at risk.
A chikungunya vaccine gave encouraging results in an early-stage clinical trial. A vaccine could prevent outbreaks of the disease, which recently reached the U.S. mainland.
Scientists determined the detailed structural states of the glutamate receptor, which is involved in learning, memory, and several diseases.
August 18, 2014
Researchers found 108 genetic regions linked to schizophrenia, including 83 previously unrecognized. The findings suggest new avenues for potential treatments.
Scientists identified a gene that underlies a rare but devastating autoinflammatory condition in children. The study suggests a potential treatment for this and related diseases.
New tests rapidly and accurately diagnose Creutzfeldt-Jakob disease, an incurable and ultimately fatal neurodegenerative disorder. Such tests would have important clinical and research uses.
July 28, 2014
Depression is a common risk for people who’ve lost vision from age-related macular degeneration. A type of therapy called behavior activation can cut this depression risk in half.
Men exposed to cool temperatures for a month had an increase in brown fat along with changes in metabolism. The finding hints at new approaches to conditions such as obesity and diabetes.
Scientists used a novel microchip-based method to isolate and grow tumor cells circulating in blood. The technique provides an important step toward personalizing cancer therapy.
July 21, 2014
The drug letrozole is more effective than standard therapy in increasing live births for women with polycystic ovary syndrome—a leading cause of female infertility.
Researchers identified DNA alterations that are involved in the development of lung adenocarcinoma. The findings may lead to more targeted therapies to treat this deadly cancer.
A new technique increased the time that rat livers can remain viable outside the body. If the approach succeeds in humans, it could aid organ transplant efforts.
July 14, 2014
Adults with severe sickle cell disease were successfully treated with a stem cell transplant approach that doesn't require extensive immune-suppressing drugs.
Low blood levels of lead were associated with increased behavioral and emotional problems in young children.
Researchers gained insights into a key protein involved in ciliopathies, a class of genetic disorders that arise from defects in hair-like extensions called cilia that are found on cells throughout the body.
June 30, 2014
Variations in a gene called APOC3 are associated with lower triglyceride levels and reduced risk of heart disease. The finding suggests new approaches to lower heart disease risk.
Research into the mechanisms that underlie our ability to remember events could yield insights into the memory problems that come with normal aging and dementia.
The structure of a protein that bacteria need to spread the genes for antibiotic resistance could spur the development of novel drugs to combat multidrug-resistant bacteria.
NIH Research Matters
Bldg. 31, Rm. 5B64A, MSC 2094
Bethesda, MD 20892-2094
About NIH Research Matters
Editor: Harrison Wein, Ph.D.
Assistant Editors: Vicki Contie, Carol Torgan, Ph.D.
NIH Research Matters is a weekly update of NIH research highlights from the Office of Communications and Public Liaison, Office of the Director, National Institutes of Health.